The invention comprises a lipid nano carrier based nanogel formulation of an active ingredient and method of their preparation. The formulation is specifically useful for dermal delivery or topical application of drugs, which may be a hydrophilic drug including 5-fluorouracil (5-FU) and acyclovir, or a hydrophobic drug such as isotretinoin. The invention is illustrated by a lipid nano carrier based nanogel formulation of 5-FU. A lipid nano carrier based nanogel formulation comprising 5- FU in a concentration of 0.001% to 10% w/w. A method of preparing lipid nano carrier based nanogel formulation of an active ingredient comprises the steps of: preparation of drug loaded vesicular lipid carrier dispersion, wherein the surface of vesicles of the lipid carrier contains a surfactant, probe sonicating the drug loaded vesicular lipid carrier dispersion of step (a.) to prepare a lipid nano carrier dispersion in nanometric size range, concentrating the lipid nano carrier dispersion in nanometric range by steps of subjecting the lipid nano carrier dispersion in nanometric size range of step (b.) either to (i) rotary evaporation, or (ii) freeze drying with or without a cryoproetctant, preparation of hydrophilic gel and mixing of lipid nano carrier dispersion of step (c.) with hydrophilic gel of step (b) to form a lipid nano carrier based nanogel formulation.Linvention concerne une formulation de nano-gel basée sur un nano-vecteur lipidique pour ciblage cutané dun ingrédient actif et son procédé de fabrication. La formulation convient particulièrement bien pour administration cutanée ou topique de médicaments, qui peuvent être un médicament hydrophile comprenant un 5-fluorouracile (5-FU) et de lacyclovir, ou un médicament hydrophobe tel que lisotretinoïne. Linvention est illustrée par une formulation de nano-gel à base de nano-vecteur lipidique. Une telle formulation comprend du 5-FU à une concentration de 0,001% à 10% en poids. Un procédé de fabrication de la formulation de na
