preparation of drug loaded vesicular lipid carrier dispersion, wherein the surface of vesicles of the lipid carrier contains a surfactant, probe sonicating the drug loaded vesicular lipid carrier dispersion of step (a.) to prepare a lipid nano carrier dispersion in nanometric size range, concentrating the 1 ipid nano carrier dispersion in nanometric range by steps of subjecting the lipid nano carrier dispersion in nanometric size range of step (b.) either to (i) rotary evaporation, or (ii) freeze drying with or without a cryoproetctant, preparation of hydrophilic gel and mixing of lipid nano carrier dispersion of step (c.) with hydrophilic gel of step (b) to form a lipid nano carrier based nanogel formulation.
