BILOTTA, Joseph Anthony,CHEUNG, Adrian Wai-Hing,FIROOZNIA, Fariborz,GUERTIN, Kevin Richard,HAYDEN, Stuart,HAYNES, Nancy-Ellen,LUKACS-LESBURG, Christine M.,MARCOPULOS, Nicholas,MERTZ, Eric,QI, Lida,QIA
申请号：
ES12734923
公开号：
ES2561298T3
申请日:
2012.07.09
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula I ** Formula ** in which: R is -C (>； = O) A, -C (>； = O) OA, -C (>； = O) NHA, -C (>； = NC>； = N) A, -C (>； = NC>； = N) NHA or A； A is C1-6 alkyl, phenyl, cycloalkyl, adamantyl, heterocycloalkyl, heteroaryl, or bicyclic heteroaryl, optionally substituted with one or more A1； each A1 is independently A2 or A3； each A2 is independently hydroxy, halo or oxo； Each A3 is independently C1-6 alkyl, C1-6 alkoxy, phenyl, benzyl, heterocycloalkyl, bicyclic heterocycloalkyl, heteroaryl, amino, C1-6 amino alkyl, C1-6 dialkyl amino, amido, C1-6 alkyl ester, sulfonyl, sulfonamido, -C (>； = O), or -C (>； = O) O, optionally substituted with one or more halo, hydroxy, C1-6 alkyl, C1-6 alkoxy, phenyl, hydroxycycloalkyl, amino, C1- alkyl 6 amino, C1-6 dialkyl amino, carbamic acid tert-butyl ester, sulfonyl, C1-6 alkyl sulfonyl heterocycloalkyl or hydroxy C1-6 alkyl； R 'is H or methyl； X is CX '； X 'is H or halo； X1 is H, 2-oxazolyl, dimethyl amido or C1-6 alkyl ester； Y is CH or N； and Y1 is H, halo, C1-6 alkoxy, or halo C1-6 alkyl； or a pharmaceutically acceptable salt thereof.Un compuesto de fórmula I**Fórmula** en la que: R es -C(>；=O)A, -C(>；=O)OA, -C(>；=O)NHA, -C(>；=N-C>；=N)A, -C(>；=N-C>；=N)NHA o A； A es alquilo C1-6, fenilo, cicloalquilo, adamantilo, heterocicloalquilo, heteroarilo, o heteroarilo bicíclico, opcionalmente sustituido con uno o más A1； cada A1 es independientemente A2 o A3； cada A2 es independientemente hidroxi, halo u oxo； cada A3 es independientemente alquilo C1-6, alcoxi C1-6, fenilo, bencilo, heterocicloalquilo, heterocicloalquilo bicíclico, heteroarilo, amino, alquil C1-6 amino, dialquil C1-6 amino, amido, éster de alquilo C1-6, sulfonilo, sulfonamido, -C(>；=O), o -C(>；=O)O, opcionalmente sustituido con uno o más halo, hidroxi, alquilo C1-6, alcoxi C1-6, fenilo, hidroxi cicloalquilo, amino, alquil C1-6 amino, dialquil C1-6 amino, éster de terc-butilo de ácido carbámico, sulfonilo, alquil C1-6 sulfonilo
