A compound of Formula I or a stereoisomer, tautomer, racemic, salt, hydrate, N-oxide or solvate form thereof, wherein A1 and A2 are selected from C and N； where when A1 is C, then A2 is N； and where when A2 is C, then A1 is N； R1 is selected from -H, -halo, -OH, -C1-6 alkyl, -C3-6 cycloalkyl, -O-C1-6 alkyl, -S-C1-6 alkyl, -NR9R10, - (C>； = O ) -R4, -SO2-R4, -CN, -NR9-SO2-R4, -Het1； wherein each of said C1-6 alkyl is optionally and independently substituted with 1 to 3 substituents selected from -halo, -OH, -NR11R12, -O-C1-6 alkyl, -S-C1-6 alkyl； R2 is selected from -H, -halo, -OH, -C 1-6 alkyl, -C 3-6 cycloalkyl, -O-C 1-6 alkyl, -S-C 1-6 alkyl, - (C>； = O) - alkyl C1-6, - (C>； = O) -O-C1-6 alkyl, - (C>； = O) -NR27R28, -Het3, - (C>； = O) -Het3, -SO2-C1-6 alkyl； wherein each of said C1-6 alkyl is optionally and independently substituted with 1 to 3 substituents selected from -halo, -OH, -O-C1-6 alkyl, -S-C1-6 alkyl, -Het3, -Ar2, -NR13R14； R3 is selected from -H, -halo, -OH, -C1-6 alkyl, -C3-6 cycloalkyl, -O-C1-6 alkyl, -S-C1-6 alkyl, - (C>； = O) - alkyl C1-6, - (C>； = O) -O-C1-6 alkyl, -Het2, - (C>； = O) -Het2, - (C>； = O) -NR29R30, -SO2 C1-6 alkyl； wherein each of said C1-6 alkyl is optionally and independently substituted with 1 to 3 substituents selected from -halo, -OH, -C1-6 alkyl, -C1-6 alkyl, -NR15R16, -Het2, -Ar4； R4 is selected from -halo, -OH, -C1-6 alkyl, -O-C1-6 alkyl, -S-C1-6 alkyl, -NR17R18, -Het4； R5 and R7 are each independently selected from -H, -halo, -C 1-6 alkyl, -C 1-6 alkyl, -S-C 1-6 alkyl, -Het5, -Ar1, -C3-6 cycloalkyl, -SO2- Ar3, -SO2, -SO2-C1-6 alkyl, - (C>； = O), - (C>； = O) -C1-6 alkyl, -O- (C>； = O) -C1-6 alkyl, - (C>； = O) -O-C 1-6 alkyl； wherein each of said C1-6 alkyl is optionally and independently substituted with 1 to 3 substituents selected from -halo, -OH, -C1-6 alkyl, -C1-6 alkyl, -Het5, -NR23R24； R6 is selected from -SO2, -SO2-C1-6 alkyl, - (C>； = O), - (C>； = S), - (C>； = O) -O-C1-6 alkyl, - (C>；
