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Compounds containing substitute nitrogen
专利权人:
BRISTOL-MYERS SQUIBB COMPANY
发明人:
YADAV, Navnath Dnyanoba,BHIDE, Rajeev S.,BORA, Rajesh Onkardas,GUNAGA, Prashantha,PANDA, Manoranjan,PRIESTLEY, Eldon Scott,RICHTER, Jeremy
申请号:
PE2019002492
公开号:
PE20200386A1
申请日:
2018.05.31
申请国别(地区):
PE
年份:
2020
代理人:
摘要:
It refers to a formula compound I or a salt, whose characteristics are: each W is an independent N1b or O; Z is a link or ch1d; X is an independent n or CR1; each R1a is an independent h, F, Cl, etc.; each r1b is an independent h, c1-3 tar, etc.; r1c is an independent h, deuterium, C1-4 tar, etc. Others; r1d is h, c1-3 tar, C1-4 fluorine quilo, etc.; and es-c (R6) 2 -,-C(R6)2-C(R6)2-,V is - O, among other things-NR4…L1 es-c (R) 2 -,-C(=O)Among other things, R is an independent h, F, oh, among others; b ring is phenyl, pyridine, etc.; R2 is arilo C6-10, or 5-10 different rings, including 1-4 kinds of heterogeneity selected from n, O and S; R3a is h, halo, oh, etc.; R3b is h, u, c1-3 Baibai reservoir, etc.; each RD is an independent h, F, C1-3, etc.; n is 0, 1 or 2. These heterocyclic compounds contain substitutes, which inhibit the activity of potassium channels (ROMK) in exonephros jellyfish;Useful in the treatment of cardiovascular diseases It also refers to intermediate compounds, methods for their production and pharmacological synthesis containing these components.Referido a un compuesto de formula I, o una sal del mismo, caracterizado porque cada W es independientemente NR1b u O; Z es un enlace o CHR1d; X es independientemente N o CR1; cada R1a es independientemente H, F, Cl, entre otros; cada R1b es independientemente H, alquilo C1-3, entre otros; R1c es independientemente H, deuterio, alquilo C1-4, entre otros; R1d es H, alquilo C1-3, fluoroalquilo C1-4, entre otros; Y es -C(R6)2-, -C(R6)2-C(R6)2-, entre otros; V es -O-, -NR4-, entre otros; L1 es -C(R)2-, -C(=O)-, entre otros; en donde R es independientemente H, F, OH, entre otros; el anillo B es fenilo, piridinilo, entre otros; R2 es arilo C6-10, o un anillo heterociclo de 5 a 10 elementos que contienen 1 a 4 heteroatomos seleccionados de N, O y S; R3a es H, halo, OH, entre otros; R3b es H, =O, alquilo C1-3, entre otros; cada Rd es independientemente H, F, alquilo C1-3, entre otros; y n es 0, 1 o 2. Estos co
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