PROCÉDÉ DE PRÉPARATION DE CELLULES DENDRITIQUES À EXPRESSION AUGMENTÉE D'UN GÈNE SPÉCIFIQUE, ET COMPOSITION POUR LE TRAITEMENT OU LA PRÉVENTION DE MALADIES AUTO-IMMUNES, CONTENANT DES CELLULES DENDRITIQUES PRÉPARÉES À L'AIDE DE CELUI-CI
The present invention relates to a method for generating semi-mature dendritic cells by treating immature dendritic cells with the auto-antigen, cytokine, and PGE2 as a target for the treatment of autoimmune diseases, particularly rheumatoid arthritis, in which the levels of NR4A2 and/or UBASH3B at gene or protein are increased more than 2-fold compared to the immature dendritic cells In addition, the present invention relates to a cell therapeutic agent for treating or preventing autoimmune diseases, containing the semi-mature dendritic cells as an active ingredient. The present invention increases the therapeutic efficacy on rheumatoid arthritis retaining responsiveness to the same auto-antigen that being used for preparing semi-mature dendritic cells, thereby enabling cell therapy.
