A biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and at least one closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a non-homogeneous external surface comprising individual clusters of flat crystal platelets consisting of epitactically grown HAP nanocrystals and coarse areas between the individual clusters, whereby the percentage of the coarse areas between the individual clusters as measured by SEM is at least 20% of the total surface, which material shows an increased capacity to induce bone formation, and a process of preparation thereof.本發明係關於一種兩相磷酸鈣/羥基磷灰石(CAP/HAP)骨替代材料，該材料顯示增加之誘導骨形成之能力，其具有燒結CAP核及至少一個封閉的奈米晶HAP磊晶生長層，該磊晶生長層沈積於該燒結CAP核之外表面上，其中磊晶生長的奈米晶體具有與人類骨礦物質相同的尺寸及形態，其中沈積於該燒結CAP核之外表面上的該封閉的奈米晶HAP磊晶生長層具有非均質外表面，其包含由磊晶生長的HAP奈米晶體組成之扁平晶體薄片之獨立團簇及該等獨立團簇之間的粗糙區域，其中如藉由SEM所量測，該等獨立團簇之間的該等粗糙區域之百分比為總表面之至少20%；及一種製備其之方法。
