A mobility assistance system includes a drive unit, a modular structural frame having a central module, and at least one side module. The central module is configured to drive at least one wheel of the mobility assistance system. The drive unit is arranged in one of the central module or the at least one side module and the at least one wheel is associated with the side module. The central module and the at least one side module each have at least one interface, by means of which the central module can be reversibly coupled mechanically electronically to the at least one side module.
