KANE, JOHN L. JR.,KOTHE, MICHAEL,SCHOLTE, ANDREW,MATTHEWS, GLORIA,METZ, MARKUS,LIU, JINYU
申请号：
PE0007602016
公开号：
PE09922016A1
申请日:
2014.12.10
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
Relates to compounds of formula (i) and the pharmaceutically acceptable salts thereof, wherein n is 1, 2, 3, 4 or 5 M is 0, 1, 2, 3 or 4 Q1 is H, Halo, c6\u2013c14 aryl aryl, among others Q2 is c6\u2013c14,C3\u2013c10 cycloalkyl, among others X is n or CH, among others r1 is H, alkyl, Halo, c1\u2013c10, NH2, among others R2 is H, alkyl, Halo, c1\u2013c10, NH2, among others R3 and R4 are independently h,Rent c1\u2013c10, o\u2013alquilo c1\u2013c10, NH2, among others or \u2013cr3r4 form a Ring 3 to 10 members, optionally substituted with 1 to 4 substituents selected from alkyl c1\u2013c10,C3\u2013c10 cycloalkyl, Oh, NH2, among others R5 and R6 are independently h, alkyl c1\u2013c10, o\u2013alquilo c1\u2013c10, NH2, among others or \u2013cr5r6 form a Ring 3 to 10 members,Optionally substituted with 1 to 4 substituents selected from c1\u2013c10 c3\u2013c10 alkyl, cycloalkyl, Oh, NH2, among others.These compounds are inhibitors of the Tropomyosin related Kinase (TRK inhibitors), which are useful in the treatment of inflammatory diseases, autoimmune diseases,Defects of bone Metabolism and cancerSe refiere a compuestos de Formula (I) y sales farmaceuticamente aceptables de los mismos, donde n es 1, 2, 3, 4 o 5 m es 0, 1, 2, 3 o 4 Q1 es H, halo, arilo C6–C14, entre otros Q2 es arilo C6–C14, cicloalquilo C3–C10, entre otros X es CH o N, entre otros R1 es H, halo, alquilo C1–C10, NH2, entre otros R2 es H, halo, alquilo C1–C10, NH2, entre otros R3 y R4 son independientemente H, alquilo C1–C10, O–alquilo C1–C10, NH2, entre otros o –CR3R4 forman un anillo de 3 a 10 miembros, opcionalmente sustituido con 1 a 4 sustituyentes seleccionados entre alquilo C1–C10, cicloalquilo C3–C10, OH, NH2, entre otros R5 y R6 son independientemente H, alquilo C1–C10, O–alquilo C1–C10, NH2, entre otros o –CR5R6 forman un anillo de 3 a 10 miembros, opcionalmente sustituido con 1 a 4 sustituyentes seleccionados entre alquilo C1–C10, cicloalquilo C3–C10, OH, NH2, entre otros. Dichos compuestos son inh
