Refers to a compound of formula (1) where a is heterocicloalquilo cycloalkyl C3 C3, C8, C10, C15 C5 C6 aryl, heteroaryl substituted - C12 or not with one or more r1 b is a Ring System carbociclico or heterobiciclico C9 - C11 replaced or not with one or more x R2 choose between or and CH2, S R1 and R2 are each C1 - C6 h, alkyl, cycloalkyl or C3 - C10, =, = S, among others R3 is H, halogen,- ORC, ocf3, SRC, among others RC is a radical selected from H or alkyl aryl C6 C1 - 6 - 10 - 16, arylalkyl C7, among others. Preferred compounds are (2), (3), among others. Also referred to a Pharmaceutical composition. These compounds are inhibitors of the tyrosine kinase being useful in the treatment of diseases related to excessive or abnormal Cell ProliferationSE REFIERE A UNA COMPUESTO DE FORMULA (1) DONDE: A ES CICLOALQUILO C3-C10, HETEROCICLOALQUILO C3-C8, ARILO C6-C15, HETEROARILO C5-C12 SUSTITUIDO O NO CON UNO O MAS R1 B ES UN SISTEMA DE ANILLOS CARBOCICLICO O HETEROBICICLICO C9-C11 SUSTITUIDO O NO CON UNO O MAS R2 X SE SELECCIONA ENTRE O, S Y CH2 R1 Y R2 SON CADA UNO H, ALQUILO C1-C6, CICLOALQUILO C3-C10, =O, =S, ENTRE OTROS R3 ES H, HALOGENO, -ORc, -OCF3, -SRc, ENTRE OTROS Rc ES H O UN RADICAL SELECCIONADO ENTRE ALQUILO C1-6, ARILO C6-10, ARILALQUILO C7-16, ENTRE OTROS. SON COMPUESTOS PREFERIDOS (2), (3), ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSCION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA TIROSINA QUINASA SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON PROLIFERACION CELULAR EXCESIVA O ANOMALIA
