COOYMANS, Ludwig Paul,DEMIN, Samuël Dominique,HU, Lili,JONCKERS, Tim Hugo Maria,RABOISSON, Pierre Jean-Marie Bernard,TAHRI, Abdellah,VENDEVILLE, Sandrine Marie Helene
申请号：
ES11794794
公开号：
ES2575232T3
申请日:
2011.12.16
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound that satisfies the formula I, N-oxide, addition salt, quaternary amine, metal complex, or a stereochemically isomeric form thereof； in which each X is independently C or N； at least one X>； = N； each Y is independently C or N； R1 is present when X>； = C and R1 is selected from the group of H, halogen, C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 alkoxy, N (R5) 2, CO (R6), CH2NH2, CH2OH, CN, C (>； = NOH) NH2, C (>； = NOCH3) NH2, C (>； = NH) NH2, CF3, OCF3, and B (OH) 2； B (O-C1-C6 alkyl) 2； R1 is absent when X>； = N R2 - (CR7R8) n-R9； R3 is selected from the group consisting of H, C1-C10 alkyl optionally including a cycloalkyl moiety selected from methylcyclopropyl or ethylcyclopropyl, C3-C7 cycloalkyl, C2-C10 alkenyl, SO2-R7, CH2CF3 or a saturated ring of 4 to 6 members containing an oxygen atom； R4 is present when Y is C, and is selected from the group consisting of H, C1-C6 alkyl, C1-C6 cycloalkyl, C1-C6 alkoxy, CO (R7), COO (R7), CF3 and halogen, R5 is selected from the group consisting of H, C1-C6 alkyl, COOCH3, and CONHSO2CH3； R6 is selected from the group consisting of OH, O (C1-C6 alkyl), NH2, NHSO2N (C1-C6 alkyl) 2, NHSO2NHCH3, NHSO2 (C1-C6 alkyl), NHSO2 (C3-C7 cycloalkyl) , and N (C1-C6 alkyl) 2； R7 and R8 are each independently selected from H, C1-C10 alkyl which optionally includes a cycloalkyl moiety selected from methylcyclopropyl or ethylcyclopropyl, C3-C7 cycloalkyl, or R7 and R8, taken together form an aliphatic ring from 4 to 6 members optionally containing a heteroatom selected from the group N, S, O； R9 is selected from the group consisting of H, R10, C1-C6 alkyl, OH, CN, F, CF2H, CF3, CONR7R8, COOR7, CON (R7) SO2R8, CON (R7) SO2N (R7R8), NR7R8, NR7COOR8 , OCOR7, O-Benzyl, NR7SO2R8, SO2NR7R8, SO2R7, OCONR7R8, OCONR7R10, N (R7) CON (R7R8), N (R7) COOR10； phthalimido, 2-methyl-benzothiophene (1,1) dioxide, or a saturated 4- to 6-membered ring containing an oxygen atom； n is an integer from 2 to 6； R10 is selected from the group consis
