Christophe Pierre Edouard Naz,Anandkumar Nandakumar,Oleg Svanidze,Martijn Antonius Johannes Cox,Fabio Zomer Volpato
申请号：
US15763197
公开号：
US20180274131A1
申请日:
2016.10.03
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Endoluminal and other as implantable prostheses are fabricated in electrospinning apparatus including a target and an applicator. A solution comprising a polymer and a solvent is directed to the target with a first electrical potential between the target and the applicator to produce a first set of fibers. The same or another solution is continued to be delivered through the applicator onto the target while applying a second electrical potential to produce a second set of fibers having a second solvent fraction, and the same or different solution may be delivered while applying a third potential difference to produce a laminated structure having at least three layers. By properly controlling the electrical potentials and solvent fractions, an adhesive layer can be formed to serve a glue or adhesive between the inner and outer layers, and a stent or other scaffold may be positioned between the inner and outer layers to form a covered stent or graft.
