DE MARCO, STEVEN J.,MOEHLE, KERSTIN,HENZE, HEIKO,SELLIER, ODILE,JUNG, FRANCOISE,GOMBERT, FRANK,OBRECHT, DANIEL,LUDIN, CHRISTIAN
申请号：
ES05707463
公开号：
ES2453540T3
申请日:
2005.02.17
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of formula ** Formula ** in which it is a dipeptide residue composed of two different amino acid building blocks, the DPro-LPro dipeptide being, and Z is an undecapeptide chain composed of eleven amino acid residues, in which the residue P1 is the residue of Nle, Ile, Aoc, hLeu, Chg, OctG, hPhe, 4AmPhe, Cha, Phe, Tyr, 2Cl-Phe, Trp, 1-Nal, or Leu； the residue P2 is the residue of Cys, Glu, Nle, Thr, or Gln； the residue P3 is the residue of Thr, Ala or Abu； the residue P4 is the residue of Lys, Nle, Ala, Abu, or Thr； the residue P5 is the residue of Ser, AlloThr, or Dpr； the residue P6 is the residue of Ile, C5al, Leu, Nle, Aoc, OctG, Cha, hLeu, hPhe, Chg, t-BuA, Glu or Asp； residue P7 is the residue of Pro； residue P8 is the residue of Pro, Ala or Pro (4NHCOFe)； the residue P9 is the residue of Tyr, Phe, Ile, Nle, Cha, Gln, Arg, Lys, His, or Thr； residue P10 is the residue of Cys, Arg, Nle, Gln, Lys, Met, Thr, or Ser, and residue P11 is the residue of Tyr, Gln, Arg, Ser, Nle, 2-Nal, 2Cl-Phe, Cha, Phg, Phe, Asp, Asn, or Thr, two Cys residues, which are present as residues P2 and P10, are linked by a bisulfide bridge formed by the replacement of the two -SH groups in the two Cys residues by a group -SS-, in free form or in the form of a pharmaceutically acceptable salt.Compuesto de fórmula **Fórmula** en la que es un residuo de dipéptido compuesto por dos bloques de construcción de aminoácidos diferentes, siendo el dipéptido DPro-LPro, y Z es una cadena de undecapéptido compuesta de once residuos de aminoácidos, en el que el residuo P1 es el residuo de Nle, Ile, Aoc, hLeu, Chg, OctG, hPhe, 4AmPhe, Cha, Phe, Tyr, 2Cl-Phe, Trp, 1-Nal, o Leu； el residuo P2 es el residuo de Cys, Glu, Nle, Thr, o Gln； el residuo P3 es el residuo de Thr, Ala o Abu； el residuo P4 es el residuo de Lys, Nle, Ala, Abu, o Thr； el residuo P5 es el residuo de Ser, AlloThr, o Dpr； el residuo P6 es el residuo de Ile, C5al, Leu, Nle, Aoc, OctG, Cha, hLeu, hPhe, Chg, t-BuA, Glu o Asp； el resid
