The Board of Trustees of The Leland Stanford Junior University
发明人:
COCHRAN, Jennifer R.,KAPUR, Shiven,BLUMENKRANZ, Mark S.
申请号：
EP16737999
公开号：
EP3244908A4
申请日:
2016.01.15
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Provided herein are VEGF variant polypeptides and Fc-VEGF variant polypeptide fusions, comprising a first VEGF monomer joined to a second VEGF monomer by a peptide linker or a disulfide bridge. In some embodiments, the VEGF variant polypeptides comprise the formula: A-L-B, wherein A is a first VEGF monomer subunit； B is a second VEGF monomer subunit； and L is a peptide linker having 14 to 20 amino acids. In certain embodiments, disclosed herein, are methods of treating an angiogenic disorder in an individual in need thereof, comprising administering to the individual a VEGF variant polypeptide or an Fc-VEGF variant polypeptide fusion. In certain embodiments, disclosed herein, are kits comprising a VEGF variant polypeptide or Fc-VEGF variant polypeptides.
