The present invention refers to compounds, and to pharmaceutical compositions containing said compounds, of the following formula (I) or a pharmaceutically acceptable salt thereof: including any stereochemically isomeric form thereof, wherein: R 1 is independently selected from the group consisting of aliphatic, aromatic or heteroaromatic ring, optionally substituted by one or more substituents chosen from the group consisting of C 1 -C 4 alkyl optionally substituted by one or more halogen atom(s), halogen, C 1 -C 4 alkoxy； R 2 is independently selected from the group consisting of aliphatic, heteroaliphatic, aromatic or heteroaromatic ring, bicyclic aliphatic, heteroaromatic or aromatic ring, C 1 -C 6 alkyl, alkenyl or alkynyl chain, optionally substituted by one or more substituents chosen from the group consisting of C 1 -C 4 alkyl optionally substituted by one or more halogen atom(s), halogen, C 1 -C 4 alkoxy, cyano, C 1 -C 4 alkylthio, SO-C 1 -C 4 alkyl, SO 2 -C 1 -C 4 alkyl, N(C 1 -C 4 alkyl) 2 ； n is 0, 1 or 2； R 3 and R 4 can be, independently, -H, -F, C 1 -C 4 alkyl, -OH, -OC 1 -C 4 alkyl； X is O, S, CH 2 , CH-C 1 -C 4 alkyl, -NH or -NC 1 -C 4 alkyl； R 5 is -H or -CH 3 optionally substituted by one or more fluorine atoms. The compounds of the invention can be used in treatment of conditions or diseases mediated by P2X7 receptor.La présente invention concerne des composés de formule (I) suivante ou un sel pharmaceutiquement acceptable de ceux-ci, des compositions pharmaceutiques les contenant et un procédé de préparation desdits composés : formule (I), dans laquelle : R1 est indépendamment choisi parmi un atome d'hydrogène, un groupe amine, un cycle aliphatique, aromatique, hétéroaliphatique ou hétéroaromatique, monocyclique ou bicyclique, éventuellement substitué par un ou plusieurs substituants choisis parmi un alkyle en C1-C4 éventuellement substitué par un ou plusieurs atomes d'halogène, halogène, groupe alcoxy en C1-C
