HARICHIAN, BIJAN,比詹 海瑞琴恩,比詹 海瑞琴恩,ROSA, JOSE GUILLERMO,荷西 吉略摩 罗莎,荷西 吉略摩 羅莎,BARRATT, MICHAEL JAMES,麦可 詹姆斯 巴瑞特,麥可 詹姆斯 巴瑞特,BOSKO, CAROL ANNETTE,卡萝 安娜特 波斯可,卡蘿 安娜特 波斯可,BAJOR, JOHN STEVEN,约翰 史蒂芬 巴爵,約翰 史蒂芬 巴爵
申请号：
TW094105889
公开号：
TWI391145B
申请日:
2005.02.25
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The bright cumarin derivative compounds (coumarin derived compounds) for disclosing Yi Seed Formulas I of this Hair, can other Pi Skin gain Elixirs and Mei Rong Yong Load Body Knot of Single Independence Huo With cooperations As Pi Skin whitenings Elixirs:Wherein R1And/or R2Ge Do or both represents Hydrogen (H)Straight Chain or branch Chain, Eat and/or the not C1 of Eat sums- C12Alkyl, alkenyl, the good As alkoxies of anilide , Huo Miscellaneous alkyl Ji Mission (More)And R3Represent straight Chain or branch Chain, Ring Like Huo non-Ring Like, Eat and/or the not C1 of Eat sums- C12Alkyl, alkenyl, Ring alkyl, Ring alkenyl , Huo Miscellaneous Wan Ji MissionAnd R4Represent a Hydrogen atoms (H)Straight Chain or branch Chain, Ring Like Huo non-Ring Like, Eat and/or not the Eat and C1 with or without Yi Miscellaneous atoms- C22Alkyl, alkenyl, Ring alkyl, Ring alkenyl, Miscellaneous alkyl, Fang Ji Huo Miscellaneous Fang Ji Ji Mission.It is applied in example in a best Ju Body Real, R1,R2And R4Respectively represent H , Tong Time R3Represent monomethyl Ji Mission, As 4- methyl 7- Hydroxyalkyl bases-coumarin derivative of what this Wen Zhong Said, or cumarin spreads out raw Inter benzenediols (resorcinol) derivative, can act on Come System Prepare by Will 4- methyl 7- Hydroxyalkyl bases-cumarin hydrolysis Hou The catalysis Elixirs (Nickel or Palladium are catalyzed Elixirs) Hydrogenization. The bright compound, Group of this Hair close object and method, and there is effect Pi Skin whitening effects, Di Pi Skin irritation , And and cost-effective and phase When Rong Yi System to make.The bright also announcement Yi Seed of this Hair make the method with the bright compounds of this Hair of general formula I with 4- substitution -7- Hydroxyalkyl base-Xiang Dou Su System.本發明揭示一種式I之香豆素衍生化合物(coumarin derived compounds),其可單獨或與其他皮膚增益劑及美容用載體結合作為皮膚美白劑:其中R1和/或R2各別或二者均代表氫(H);直鏈或支鏈、飽和或不飽和之C1-C12烷基、烯基、醯基,或雜烷基基團(較佳為烷氧基);以及R3代表直鏈或支鏈、環狀或非環狀、飽和或不飽和之C1-C12烷基、烯基、環烷基、環烯基,或雜烷基團;以及R4代表一氫原子(H);直鏈
