PROBLEM TO BE SOLVED: To provide a method for creating a cancer metastasis model animal in which all processes of cancer metastasis are reproduced, and a screening method for a cancer metastasis inhibitor using the model animal.SOLUTION: The method for creating a model mouse for distant metastasis of the human epithelial cell cancer includes: transplanting human cancer epithelial cell retaining the form of the epithelial cell, the cell membrane of which shows positive for E-cadherin, under the skin of NOG mouse and causing to develop distant metastasis.COPYRIGHT: (C)2014,JPO&INPIT【課題】癌転移過程の全てが再現された癌転移モデル動物の作出方法、当該モデル動物を用いた癌転移抑制剤のスクリーニング方法を提供する。【解決手段】細胞膜のE-カドヘリン陽性の上皮細胞の形態を維持したヒト癌上皮細胞を、NOGマウスの皮下に移植し、癌を遠融転移させることを特徴とするヒト上皮癌転移モデルマウスの作出方法。【選択図】なし
