PAMELA KAY KREEGER,MOLLY JANE CARROLL,KAITLIN C. FOGG
申请号：
US16256065
公开号：
US20190241665A1
申请日:
2019.01.24
申请国别(地区):
US
年份:
2019
代理人:
摘要：
As described herein, a method of inhibiting metastasis in cancer includes administering to a human subject diagnosed with a cancer of an organ of the peritoneal cavity a therapeutically effective amount of an inhibitor of CCR5 or P-selectin. Preferably the subject has a tumor positive for a ligand of P-selectin such as a CD24+ or PSGL-1+ tumor. Analysis of samples from HGSOC patients confirmed increased MIP-1β and P-selectin, suggesting that this novel multi-cellular mechanism can be targeted to slow or stop metastasis in cancers such as high-grade serous ovarian cancer, for example by using anti-CCR5 and P-selectin therapies developed for other indications.
