Small molecule calpain modulator compounds, including their pharmaceutically acceptable salts, can be included in pharmaceutical compositions. The compounds can be useful in inhibiting calpain, or competitive binding with calpastatin, by contacting them with CAPN1, CAPN2, and/or CAPN9 enzymes residing inside a subject. The compounds and composition can also be administered to a subject in order to treat a fibrotic disease or a secondary disease state or condition of a fibrotic disease.本發明係關於小分子鈣蛋白酶(calpain)調節劑化合物，包括其醫藥上可接受之鹽，其可包含在醫藥組合物中。該等化合物可用於藉由使化合物與存在於個體體內的CAPN1、CAPN2及/或CAPN9酵素接觸來抑制鈣蛋白酶，或與鈣蛋白酶抑素(calpastatin)競爭性結合。亦可將該等化合物及組合物投與給個體以治療纖維化疾病或纖維化疾病之繼發性疾病狀態或病情。
