An orthosis (1) for support of a patient's wrist, hand and/or fingers, comprising a substantially rigid wire frame (2) which is shaped and configured to directly engage a patient's wrist, hand and/or fingers in snug fashion for support thereof. The wire frame (2) comprises one or more longitudinally extendible and retractable wire frame adjusters (3) for loosening or tightening the wire frame (2), wherein each of the wire frame adjusters (3) comprises a first frame end section (4) and a second frame end section (5) in side-by-side engagement, wherein the first and second frame end sections (4,5) are laterally immovable whilst being longitudinally movable with respect to each other. Each of the wire frame adjusters (3) is positioned at a predetermined location with respect to the wire frame (2) for providing longitudinal extension and retraction thereof at the predetermined location.
