KIM YONG SUNG,CHOI DONG KI,SHIN SEUNG MIN,KIM SUNG HOON
申请号：
IN201747004189
公开号：
IN201747004189A
申请日:
2017.02.06
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present invention relates to a method for suppressing RAS activated in a cell by using an antibody having cytoplasm penetration capacity and complete immunoglobulin form. In addition the present invention relates to a heavy chain variable region (VH) that induces bonding with RAS activated in a cytoplasm by means of the active penetration by an antibody having complete immunoglobulin form of the cytoplasm of a living cell by endocytosis and endosomal escape and an antibody comprising same. Also the present invention relates to a method for treating cancer or tumors or for inhibiting the growth of cancer or tumor cells by using the antibody. The present invention also relates to a method for screening a heavy chain variable region that specifically bonds to RAS in a cytoplasm. The present invention also relates to a bioactive molecule fused to the antibody. The present invention also relates to a composition for preventing treating or diagnosing cancer comprising the antibody or the bioactive molecule fused to same. The present invention also relates to a polynucleotide that codes a light chain variable region and the antibody.
