Georg Hoffmann;Dennis Fiegen;Guenter Linz;Jasna Klicic;Edward Walker;Andreas Schnapp;Michael Philip Mazanetz;Robert John Scott;Stephen Peter East;Gerhard Schaenzle;Sandra Handschuh;Matthias Hoffmann
发明人:
Matthias Hoffmann,Georg Hoffmann,Dennis Fiegen,Sandra Handschuh,Jasna Klicic,Guenter Linz,Gerhard Schaenzle,Andreas Schnapp,Stephen Peter East,Michael Philip Mazanetz,Robert John Scott,Edward Walker
申请号：
US13013973
公开号：
US20120028939A1
申请日:
2011.01.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to new substituted naphthyridines of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof,whereinR1 is selected from among —O—R3 or —NR3R4,R3 is C1-6-alkyl which is substituted by R5 and R6,R5 is selected from hydrogen, branched or linear C1-6-alkyl, C2-6-alkenyl, —C1-6-alkylen-O—C1-3-alkyl, C1-3-haloalkyl,R6 is ring Xwherein n is either 0 or 1,and is a either a single or a double bond andwherein A, B, D and E are each independently from one another selected from CH2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, —C1-3-alkyl, —C1-3-haloalkyl, —O—C1-3-alkyl, —C1-3-alkanol and halogen,and wherein R4, R2, R7, R8, R9, R10, R11 and Q may have the meanings as given in claim 1, as well as pharmaceutical compositions containing these compounds.
