The present invention relates to a heterocyclic compound having the effects of treating and preventing inflammatory diseases and healing skin wounds, and particularly, having the effects of restoring damaged skin barriers and relieving inflammation and pruritus resulting from inflammatory skin diseases. A composition including the compound of the present invention as an active ingredient may be used to relieve various inflammatory diseases and diseases in which the expression of protease activated receptor-2 (PAR-2) is increased. Particularly, the composition including the compound of the present invention as an active ingredient inhibits the activity of PAR-2 in the skin, and therefore can be used as an anti-inflammatory composition for inflammatory skin diseases such as atopic dermatitis.La présente invention concerne un composé hétérocyclique ayant pour effets de traiter et de prévenir des maladies inflammatoires et de guérir des plaies cutanées, et en particulier, ayant pour effets la restauration des barrières cutanées endommagées et le soulagement de l'inflammation et du prurit résultant de maladies cutanées inflammatoires. Une composition incluant le composé de la présente invention comme ingrédient actif peut être utilisée pour soulager diverses maladies inflammatoires et des maladies dans lesquelles l'expression du récepteur-2 activé par la protéase (PAR-2) est augmentée. En particulier, la composition incluant le composé de la présente invention comme ingrédient actif inhibe l'activité de PAR-2 dans la peau, et par conséquent peut être utilisée comme composition anti-inflammatoire pour des maladies cutanées inflammatoires comme la dermatite atopique.본 발명에 따른 헤테로고리 화합물은 염증성 질환의 치료 및 예방 효과와 피부 상처치유 효과를 지니며, 특히 염증성 피부 질환에 있어 손상된 피부장벽의 회복효과와 염증 완화, 소양증 완화 효과를 나타내며 본 발명의 화합물을 유효성분으로 하는 조성물은 다양한 염증성 질환 및 PAR-2 (protease activated receptor-2) 수용체의 발현이 증가된 질환을 완화하기 위해 사용할 수 있으며, 특히 피부에서 PAR-2의 활성을 저해하여 아토피 피부염 등을 포함한 염증성 피부질환에 있어 항염 기능을 지닌 조성물로서 사용이 가능하다.
