DERIVE DE PURINYLPYRIDINYLAMINO-2,4-DIFLUOROPHENYL SULFONAMIDE, SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CELUI-CI, SON PROCEDE DE PREPARATION, ET COMPOSITION PHARMACEUTIQUE AY ANT UNEACTIVITE INHIBITRICE CONTRE LA RAF KINASE, LE CONTENANT COMME PRINCIPE ACTIF
SHIM, EUN KYONG,KIM, NAM DOO,SHIM, TAE BO,KIM, SEUNG YONG
申请号：
CA2820550
公开号：
CA2820550C
申请日:
2011.11.25
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
A purinylpyridinylamino-2,4-difluorophenyl sulfonamidederivative of formula (see above formula) apharmaceuticallyacceptable salt thereof, a preparation method thereof, anda pharmaceutical composition with an inhibitory activityagainst Raf kinase, containing the same as an activeingredient are provided. The purinylpyridinylamino-2,4-difluorophenylsulfonamide derivative of the presentinvention effectively regulates the activity of B-Rafkinase, and thus may be useful for preventing or treatingcancers induced by the over-activation of Raf kinase,especially various melanoma, colorectal cancer, prostatecancer, thyroid cancer, ovarian cancer and the like.
