DÉRIVÉ DE PURINYLPYRIDINYLAMINO-2,4-DIFLUOROPHÉNYL SULFONAMIDE, SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CELUI-CI, SON PROCÉDÉ DE PRÉPARATION, ET COMPOSITION PHARMACEUTIQUE AYANT UNE ACTIVITÉ INHIBITRICE CONTRE LA RAF KINASE, LE CONTENANT COMME PRINCIPE ACTIF

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专利权人:

MEDPACTO INC.

发明人:

申请号：

EP11844745.7

公开号：

EP2647637B1

申请日:

2011.11.25

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

A novel purinylpyridinylamino-2,4-difluorophenyl sulfonamide derivative, a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition with an inhibitory activity against Raf kinase, containing the same as an active ingredient are provided. The purinylpyridinylamino-2,4-difluorophenyl sulfonamide derivative of the present invention effectively regulates the activity of B-Raf kinase, and thus may be useful for preventing or treating cancers induced by the over-activation of Raf kinase, especially various melanoma, colorectal cancer, prostate cancer, thyroid cancer, ovarian cancer and the like.

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中国工程科技知识中心

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http://www.ckcest.cn/home/