NOUVEAU COMPOSÉ OU SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CELUI-CI, ET COMPOSITION PHARMACEUTIQUE LE CONTENANT À TITRE DE PRINCIPE ACTIF

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专利权人:

SNU R&DB Foundation

发明人:

申请号：

EP12880708.8

公开号：

EP2871187B1

申请日:

2012.07.04

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The present invention relates to a novel compound inhibiting Hsp 90 and to a pharmaceutical composition including same as an active ingredient. Compounds of formula 1 and formula 2 according to the present invention inhibit the accumulation of HIF-1± protein, which is an Hsp90 client protein, by suppressing Hsp90 expression, and effectively inhibit the activity of vascular endothelial growth factor (VEGF). Furthermore, said compounds have low cytotoxicity and can thus be used as an active ingredient for the treatment of diabetic retinopathy and arthritis.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/