INDUSTRY ACADEMIC COOPERATION FOUNDATION KEIMYUNG UNIVERSITY;계명대학교 산학협력단
发明人:
SEO, Young Ho,서영호
申请号：
KRKR2017/001034
公开号：
WO2017/131500A1
申请日:
2017.01.31
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to: a novel compound having an HSP90 inhibitory activity or a pharmaceutically acceptable salt thereof； and a medical use thereof. A composition, of the present invention, containing a dihydroxyphenyl-based compound or a benzamide-based compound, which is the novel compound having HSP90 inhibitory activity, can effectively inhibit HSP90, and thus could be useful as a pharmaceutical composition for preventing or treating any one HSP90-mediated disease selected from the group consisting of cancer, degenerative neurological disorders and viral infections, or as a dietary supplement for preventing or alleviating HSP90-mediated diseases.La présente invention concerne : un nouveau composé ayant une activité inhibitrice de HSP90 ou un sel pharmaceutiquement acceptable de celui-ci ； et une utilisation médicale de celui-ci. Une composition de la présente invention, contenant un composé à base de dihydroxyphényle ou un composé à base de benzamide, qui est le nouveau composé ayant une activité inhibitrice de HSP90, peut inhiber efficacement HSP90, et peut donc être utile en tant que composition pharmaceutique pour prévenir ou traiter une maladie quelconque médiée par HSP90 choisie dans le groupe constitué du cancer, de troubles neurologiques dégénératifs et d'infections virales, ou en tant que complément alimentaire pour prévenir ou atténuer des maladies médiées par HSP90.HSP90 억제 활성을 갖는 신규 화합물 또는 이의 약제학적으로 허용가능한 염 및 이의 의학적 용도에 관한 것으로, 본 발명의 HSP90 억제 활성을 갖는 신규 화합물인 디히드록시페닐(dihydroxyphenyl)계 화합물 또는 벤즈아미드계 화합물을 포함하는 조성물은 HSP90을 효과적으로 억제할 수 있으므로, 암 질환, 퇴행성 신경질환 및 바이러스 감염증으로 이루어진 군에서 선택된 어느 하나의 HSP90 매개 질환 예방 또는 치료용 약학 조성물, 또는 HSP90 매개 질환 예방 또는 개선용 건강기능식품으로 유용하게 사용될 수 있다.
