PROBLEM TO BE SOLVED: To provide a material that can enhance efficiently regulatory T-cells, is useful for prevention and treatment of autoimmune disease or inflammatory disease and is highly safe, and serves as an active ingredient of medicine or food.SOLUTION: A regulatory T-cell enhancer containing trehalose, highly safe for living bodies, as an active ingredient is used as an agent for prevention and treatment of autoimmune disease or inflammatory disease, such as type 1 diabetes mellitus.SELECTED DRAWING: Figure 4COPYRIGHT: (C)2019,JPO&INPIT【課題】効率よく制御性T細胞を増強でき、自己免疫疾患又は炎症性疾患の予防や治療に有効かつ安全性の高い、医薬又は食品の有効成分となりうる物質を提供すること。【解決手段】生体への安全性の高いトレハロースを有効成分とする制御性T細胞増強剤を1型糖尿病などの自己免疫疾患又は炎症性疾患の予防又は治療剤として使用する。【選択図】図4