BARBERA BETANCOURT, ARIANA,DOMINGUEZ HORTA, MARIA DEL CARMEN,LORENZO PEREZ, NORAILYS,PADRON PALOMARES, GABRIEL RAMON,FALCON CAMA, VIVIANA,MENENDEZ VALDES, IVON
申请号：
AU2012100293
公开号：
AU2012100293A4
申请日:
2012.03.16
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
USE OF AN APL PEPTIDE FOR THE TREATMENT OF INFLAMMATORY BOWEL 5 DISEASE AND TYPE I DIABETES The present invention is related with the field of the medicine, particularly with the use of an APL peptide or its analogues derived from the human heat shock protein of 60 kDa, for the manufacture of a pharmaceutical composition for the treatment of 10 Crohns disease, ulcerative colitis and diabetes mellitus type 1. This peptide is biodistributed into the gastrointestinal tract and also promotes the induction of apoptosis in activated intestinal lamina propria and peripheral blood T cells of patients with Crohns disease. Furthermore, this peptide induces apoptosis in mononuclear cells of patients with diabetes mellitus type 1. C:\pqof0ordSPEC-919557 doc
