Norailys Lorenzo Perez;Gabriel Ramon Padron Palomares;Maria del Carmen Dominguez Horta;Ariana Barbera Betancourt;Viviana Falcon Cama;Ivon Menendez Valdes
发明人:
Ariana Barbera Betancourt,Maria del Carmen Dominguez Horta,Norailys Lorenzo Perez,Gabriel Ramon Padron Palomares,Viviana Falcon Cama,Ivon Menendez Valdes
申请号：
US13142471
公开号：
US20120035106A1
申请日:
2009.12.29
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is related with the field of the medicine, particularly with the use of an APL peptide or its analogues derived from the human heat shock protein of 60 kDa, for the manufacture of a pharmaceutical composition for the treatment of Crohn's disease, ulcerative colitis and diabetes mellitus type 1. This peptide is biodistributed into the gastrointestinal tract and also promotes the induction of apoptosis in activated intestinal lamina propria and peripheral blood T cells of patients with Crohn's disease. Furthermore, this peptide induces apoptosis in mononuclear cells of patients with diabetes mellitus type 1.
