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Small-molecule-targeted protein degradation
专利权人:
Deviprasad R. Gollapalli;Marcus Long;Lizbeth K. Hedstrom
发明人:
Lizbeth K. Hedstrom,Marcus Long,Deviprasad R. Gollapalli
申请号:
US13805508
公开号:
US09765019B2
申请日:
2011.06.30
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Certain aspects of the invention relate to compounds, compositions and methods that are useful for treating or preventing a disease in a subject by enhancing the degradation of a protein. In other aspects, said compounds can be useful research tools for investigating protein degradation. In other aspects, said compounds are useful research tools for investigating protein function. In certain embodiments, the degraded protein is implicated in a disease or disorder whose pathology is related at least in part to the excessive expression of the protein or the expression of a mutant form of the protein.
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