ILLIG, CARL R.,伊利格,BALLENTINE, SHELLEY K.,巴兰太,巴蘭太,CHEN, JINSHENG,陈锦生,陳錦生,MEEGALLA, SANATH,玛格兰,瑪格蘭,RUDOLPH, M. JONATHAN,卢多夫,盧多夫,WALL, MARK J.,沃马可,沃馬可,WILSON, KEN,威尔森,威爾森,DESJARLAIS, RENEE,丹利斯,M
申请号：
TW094136915
公开号：
TWI377942B
申请日:
2005.10.21
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
The invention is directed to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases； and diseases with an inflammatory component； treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma； and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain； as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.本發明係關於式I化合物：；I；其中A、X、R2及W是陳述於發明說明，以及其溶劑化物、水合物、互變異構物及藥學上可接受的鹽類，其可抑制蛋白酪胺酸激酶，尤其是c-fms激酶。並提供使用式I化合物治療自發免疫疾病；具有發炎成份之疾病；治療從卵巢癌、子宮癌、乳癌、結腸癌、胃癌、毛細胞性白血病及非小肺癌之轉移；及治療疼痛包括腫瘤轉移或骨關節炎造成的骨骼疼痛、或內臟、發炎及神經性疼痛；以及骨質疏鬆、Paget氏症、及其中骨再吸收仲介發病的其他疾病包括關節炎、修復術失敗、溶骨肉瘤、骨髓瘤及腫瘤轉移至骨之方法。
