ILLIG, CARL R,艾尔林,艾爾林,BALLENTINE, SHELLEY K.,巴连汀,巴連汀,CHEN, JINSHENG,陈锦生,陳錦生,DESJARLAIS, RENEE LOUISE,德贾斯,德賈斯,MEEGALLA, SANATH K.,米格拉,TOMCZUK, BRUCE E.,汤姆克,湯姆克,WALL, MARK,沃马克,沃馬克,WILSON, KENNETH,威尔
申请号：
TW096113730
公开号：
TWI411612B
申请日:
2007.04.19
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The invention is directed to compounds of Formula I:wherein Z, X, J, R2and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases； and diseases with an inflammatory component； treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia； and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain； as well as osteoporosis, Paget’s disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.本發明係指式I化合物：其中Z、X、J、R2及W如說明書中所述，及其溶劑合物、水合物、互變異構物及醫藥可接受性鹽類，其可抑制蛋白質酪胺酸激酶，尤其是c－fms激酶。亦提供以式I化合物治療下列疾病之方法：自體免疫性疾病；及具炎症要素之疾病；由卵巢癌、子宮癌、乳癌、前列腺癌、肺癌、結腸癌、胃癌、毛髮細胞白血病之轉移；及治療疼痛，包括腫瘤轉移或骨關節炎所引起之骨骼疼痛，及內臟、炎症性、及神經性疼痛；及骨質疏鬆症、Paget氏症、及其他骨再吸收調節症狀之疾病，包括風濕性關節炎及其他形式之發炎性關節炎、骨關節炎、人工代用品衰竭、骨質溶解性肉瘤、骨髓瘤、及轉移至骨頭之腫瘤。
