PROBLEM TO BE SOLVED: To provide an excipient composed of mannitol, which has excellent chemical stability due to its less reactivity with an active ingredient, excellent storage stability due to its less hygroscopicity, and excellent palatability due to its odorless, moderate sweetness and cool feeling, and gives a tablet containing a high concentration of an active ingredient while having high strength and a tablet having excellent disintegrability when used in a disintegrator and a tablet containing the excipient.SOLUTION: An excipient to be used for compression molding is composed of a mannitol particle having an average particle diameter of 10 to 30 μm, a particle size distribution degree of 35 or less and a specific surface area of 0.3 to 1.1 m2/g. A tablet is characterized by containing 10 to 55 mass% of the excipient and 40 to 90 mass% of an active ingredient and by having a tensile strength of 0.7 MPa or more.COPYRIGHT: (C)2014,JPO&INPIT【課題】本発明の課題は、活性成分との反応性が少なく化学的安定性に優れ、吸湿性が小さく保存安定性に優れ、臭いがなく適度な甘みと清涼感を有し嗜好性に優れ、高い強度を有しながら活性成分を高濃度に含有した錠剤が得られ、崩壊剤に用いた場合には、崩壊性に優れた錠剤を得ることのできるマンニトールからなる賦形剤、及びかかる賦形剤を含有する錠剤を提供することにある。【解決手段】平均粒子径が10~30μmであり、粒度分布度が35以下であり、比表面積が0.3~1.1m2/gであるマンニトール粒子からなる、圧縮成形に用いるための賦形剤、及び上記賦形剤を10~55質量%、及び活性成分を40~90質量%含有し、引張強度が0.7MPa以上であることを特徴とする錠剤。【選択図】なし
