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AMORPHOUS LETERMOVIR AND SOLID PHARMACEUTICAL FORMULATIONS THEREOF FOR ORAL ADMINISTRATION
专利权人:
发明人:
SCHWAB WILFRIED,JUNG DIRK,SCHICKANEDER CHRISTIAN,M„RTENS WELLJANNE,LIMMERT MICHAEL,BOTHE CLEMENS,BERWE MATHIAS,RINDERMANN NICOLE
申请号:
IN201627001750
公开号:
IN201627001750A
申请日:
2016.01.18
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
eitherHerpesviridaeThe present invention provides for amorphous Letermovir and orally administrable solid pharmaceutical formulations thereof (immediate release formulation). Said amorphous Letermovir is suitable for immediate release formulations when isolated out of an organic solution by roller drying said organic solution in a volatile organic solvent in particular acetone at a temperature of 30�C to 60�C and subsequently drying the amorphous Letermovir obtained or isolating said amorphous Letermovir by precipitation from water miscible solvents selected from acetone or acetonitrile into excess water as anti solvent and subsequently filtrating or centrifuging the amorphous Letermovir obtained. The immediate release formulations of amorphous Letermovir are intended for use in methods of prophylaxis or methods of treatment of diseases associated with the group of preferably associated with cytomegalovirus (CMV) even more preferably associated with human cytomegalovirus (HCMV).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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