您的位置: 首页 > 农业专利 > 详情页

Amorphous letermovir and solid pharmaceutical formulations thereof for oral administration
专利权人:
AICURIS ANTI-INFECTIVE CURES GMBH
发明人:
Wilfried Schwab,Dirk Jung,Christian Schickaneder,Welljanne Martens,Michael Limmert,Clemens Bothe,Mathias Berwe,Nicole Rindermann
申请号:
US14899178
公开号:
US10442773B2
申请日:
2014.06.19
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention provides for amorphous Letermovir and orally administrable solid pharmaceutical formulations thereof (immediate release formulation). Said amorphous Letermovir is suitable for immediate release formulations when isolated out of an organic solution by either roller-drying said organic solution in a volatile organic solvent, in particular acetone, at a temperature of 30° C. to 60° C., and subsequently drying the amorphous Letermovir obtained, or isolating said amorphous Letermovir by precipitation from water miscible solvents selected from acetone or acetonitrile into excess water as anti-solvent, and subsequently filtrating or centrifuging the amorphous Letermovir obtained.The immediate release formulations of amorphous Letermovir are intended for use in methods of prophylaxis or methods of treatment of diseases associated with the group of Herpesviridae, preferably associated with cytomegalovirus (CMV), even more preferably associated with human cytomegalovirus (HCMV).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充