A physiological signal measurement device includes a shell, a pair of induction sheets mounted to the shell, and a circuit board assembly mounted in the shell. The circuit board assembly includes a microprocessor, a photoplethysmography sensor electrically connected with the microprocessor, and an electrocardio signal sensor. The photoplethysmography sensor senses photoplethysmography signals of blood vessels reflected by the finger parts. The electrocardio signal sensor is electrically connected with the microprocessor and the pair of the induction sheets. The pair of the induction sheets respectively contact with finger parts of two hands to form a loop for sensing trace amounts of electrical signals generated from heart beats.
