MYUNG HYUN JANG,DAE JIN KIM,SANG YOUN HWANG,HYUN UK KIM,SUNG YOUB JUNG,SE CHANG KWON
申请号：
PT14757574
公开号：
PT2963055T
申请日:
2014.02.26
申请国别(地区):
PT
年份:
2019
代理人:
摘要：
Provided are an insulin conjugate having improved insulin receptor binding affinity and increased activity, in which a non-peptidyl polymer and an immunoglobulin Fc region are site-specifically linked to an amino acid residue of the insulin beta chain excluding the N-terminus thereof via a covalent bond, a long-acting formulation including the same, and a preparation method thereof. The insulin conjugate of the present invention is used to provide an insulin formulation which exhibits a remarkably increased in vivo activity of the peptide.
