DAE JIN KIM;SANG YOUN HWANG;SUNG YOUB JUNG;MYUNG HYUN JANG;HYUN UK KIM;HANMI PHARM. CO. LTD.;SE CHANG KWON
发明人:
DAE JIN KIM,SUNG YOUB JUNG,SE CHANG KWON,SANG YOUN HWANG,MYUNG HYUN JANG,HYUN UK KIM
申请号：
IL24071415
公开号：
IL240714A
申请日:
2015.08.20
申请国别(地区):
IL
年份:
2020
代理人:
摘要：
Provided are an insulin conjugate having improved insulin receptor binding affinity and increased activity, in which a non-peptidyl polymer and an immunoglobulin Fc region are site-specifically linked to an amino acid residue of the insulin beta chain excluding the N-terminus thereof via a covalent bond, a long-acting formulation including the same, and a preparation method thereof. The insulin conjugate of the present invention is used to provide an insulin formulation which exhibits a remarkably increased in vivo activity of the peptide.
