JANG, Myung Hyun,KIM, Dae Jin,HWANG, Sang Youn,KIM, Hyun Uk,JUNG, Sung Youb,KWON, Se Chang,張明賢,金大振,黃祥淵,金賢煜,鄭聖燁,權世昌
申请号：
HK16104800.4
公开号：
HK1217202A
申请日:
2016.04.27
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
Provided are an insulin conjugate having improved insulin receptor binding affinity and increased activity, in which a non-peptidyl polymer and an immunoglobulin Fc region are site-specifically linked to an amino acid residue of the insulin beta chain excluding the N-terminus thereof via a covalent bond, a long-acting formulation including the same, and a preparation method thereof. The insulin conjugate of the present invention is used to provide an insulin formulation which exhibits a remarkably increased in vivo activity of the peptide.
