Certain genotypes could be used to help evaluating susceptibility to disease drug treatment. Including that identification of susceptibility of ototoxicity and nephrotoxicity with specific genotypes could help determine which susceptibility is higher. For example, intra-tympanic injection using gentamicin and other antibiotics injection to treat intractable vertigo for patients with MD. The result of the susceptibility determination further can evaluate giving such treatment is beneficial or not.本發明係以患者之基因型評估病患對於藥物治療易受性,包括以使用包括慶大黴素(intratympanic gentamicin;ITG)等抗生素來治療梅尼爾氏症患者之眩暈症前,先檢驗確認病患是否具有特定基因型,以為評估該治療對於患者是否有益。