DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
SONG, JAE JUN,송재준
申请号：
KR1020110082731
公开号：
KR1020130020230A
申请日:
2011.08.19
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A pharmaceutical composition containing necroX is provided to suppress hair cell damage and to prevent or treat heating loss.CONSTITUTION: A pharmaceutical composition for hearing loss contains necroX as an active ingredient. The hearing loss is sensorineural hearing loss caused by hair cell damage due to an anti-cancer drug, antibiotics, or a diuretic. The anti-cancer drug is a platinum-based anti-cancer drug such as cisplatin or carboplatin. The diuretic is acetazolamide, furosemide, bumetanide, or ethacrynic acid.COPYRIGHT KIPO 2013[Reference numerals] (AA) a,b,c : untreated(negative comparison group) (BB) d,e,f : necroX(0uM) + gentamycin(0.3mM) (CC) g,h,i : necroX(0.5uM) + gentamycin(0.3mM) (DD) j,k,l : necroX(2.5uM) + gentamycin(0.3mM) (EE) m,n,o : necroX(5uM) + gentamycin(0.3mM) (FF) p,q,r : necroX(10uM) + gentamycin(0.3mM)본 발명은 네크록스를 유효성분으로 함유하는 난청의 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명의 네크록스는 내이의 유모세포의 손상을 억제함으로써, 난청의 예방 또는 치료에 유용하게 사용될 수 있다.
