LEE, WAY ZEN,李位仁,CHIANG, CHIEN WEI,江建纬,江建緯,LIN, TSUNG HAN,林宗翰,KUO, TING SHEN,郭顶审,郭頂審
申请号：
TW101118168
公开号：
TWI449699B
申请日:
2012.05.22
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention relates to a novel nickel complex and its derivatives, which mimic the active site of Ni-containing superoxide dismutase (NiSOD). The five-coordinate Ni(II) and Ni(III) complexes or their derivatives, and six-coordinate derivatives have the following structures of formula (I) and (II): The nickel complexes and their derivatives of the invention act as anti-oxidants or free radical scavengers. The invented nickel complexes can be used in the preparation of medicals, health foods or cosmetics for human, animals and plants, or can be used in environmental or soil protection.本發明係關於一種新穎的鎳錯合物及其衍生物，可作用為含鎳超氧化物歧化酶(NiSOD)之活性中心的擬態化合物。根據本發明製得之新穎五配位二價鎳或三價鎳錯合物與其衍生物，及其六配位衍生物各具有下列結構式(I)及(II)：本發明之鎳錯合物可做為一種抗氧化劑或自由基清除劑，使用於人體或動、植物體，以防止因自由基毒害所造成之病變，可用於製備醫藥品、保健食品、化妝品組成物及環境或土壤之抗氧化劑。
