Kenneth Joseph Valenzano,John Crowley,Richie Khanna,John Flanagan
申请号：
US14379131
公开号：
US09404100B2
申请日:
2013.03.07
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present application provides for compositions comprising high concentrations of acid α-glucosidase in combination with an active site-specific chaperone for the acid α-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid α-glucosidase enzyme formulation.
