The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I)useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.本發明係關於式(I)之6-經取代異喹啉及異喹啉酮衍生物,其用於治療及/或預防與Rho-激酶及/或與肌凝蛋白輕鏈磷酸酶之Rho-激酶調控磷酸化相關之疾病,及含有此類化合物之組成物。