The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I)useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.本發明係有關式(I)之6-經取代異喹啉及異喹啉酮衍生物其可用於治療及/或預防與Rho-激酶及/或由Rho-激酶介導之肌球蛋白輕鏈磷酸酶磷酸化有關的疾病及含有該等化合物之組成物。