Ashok ARASAPPAN,Jason M. COX,John S. DEBENHAM,Zhuyan GUO,Jiafang HE,Zahid HUSSAIN,Zhong LAI,Derun LI,Dongfang MENG,Subharekha RAGHAVAN,Sriram TYAGARAJAN
申请号：
US16670093
公开号：
US20200140445A1
申请日:
2019.10.31
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention is directed to pyrazolopyrimidine compounds of the general structural formula I:which may be useful as therapeutic agents for the treatment of disorders associated with phosphodiesterase 9 (PDE9). The present invention also relates to the use of such compounds for treating cardiovascular and cerebrovascular diseases, such as hypertension, chronic kidney disease and heart failure, and neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
