Army Medical University;Chongqing Tianbaikang Biotechnology Co., Ltd.
发明人:
LI, Xiaohui,JIA, Yi,HUANG, Yan
申请号：
EP17850301
公开号：
EP3502120A4
申请日:
2017.09.15
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Provided are panaxdiol-type ginsenoside derivatives having structures as shown in formula I or formula II. Also provided are the uses thereof in the preparation of drugs for preventing and treating atherosclerosis. The panaxdiol-type ginsenoside derivatives have low cytotoxicities, can significantly reduce the percentages of the areas of atherosclerotic plaques in apoE-/-mice, can also effectively reduce the levels of low-density lipoprotein cholesterol and increase the levels of high-density lipoprotein cholesterol in serums of mice, and can significantly reduce the local TNF-α levels in the arteries of apoE -/- mice and have good anti-inflammatory effects； at a dose of 30 µM, the panaxdiol-type ginsenoside derivatives can significantly reduce the degrees of the formation of RAW264.7 cell-derived foam cells. In addition, the preparation methods for the panaxdiol-type ginsenoside derivatives are easy to operate and obtain high yields.
