ARMY MEDICAL UNIVERSITY;CHONGQING TIANBAIKANG BIOTECHNOLOGY CO., LTD.
发明人:
Xiaohui LI,Yi JIA,Yan HUANG
申请号：
US16333803
公开号：
US20190256549A1
申请日:
2017.09.15
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided are panaxdiol-type ginsenoside derivatives having structures as shown in formula I or formula II. Also provided are the uses thereof in the preparation of drugs for preventing and treating atherosclerosis. The panaxdiol-type ginsenoside derivatives have low cytotoxicities, can significantly reduce the percentages of the areas of atherosclerotic plaques in apoE−；/−；mice, can also effectively reduce the levels of low-density lipoprotein cholesterol and increase the levels of high-density lipoprotein cholesterol in serums of mice, and can significantly reduce the local TNF-α levels in the arteries of apoE−；/−；mice and have good anti-inflammatory effects； at a dose of 30 μM, the panaxdiol-type ginsenoside derivatives can significantly reduce the degrees of the formation of RAW264.7 cell-derived foam cells. In addition, the preparation methods for the panaxdiol-type ginsenoside derivatives are easy to operate and obtain high yields.
