Tim Fat Tam,Blaise N'Zemba,Regis Leung-Tuong,Yingsheng Wang,Yanqing Zhao,Lily Yu,Blaise NZemba
申请号：
US12515217
公开号：
US08119606B2
申请日:
2007.11.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D-tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1:1) is a stable pharmaceutical solid.
